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Recommendations

≥ 18 years
Дозування Ремарки
benzylpenicillin IV 2 million IU 6 times daily

+

clindamycin IV 600 mg 3 times daily

+

amikacin IV 20 mg/kg once daily

Unknown pathogen

Consider administration of immunoglobulin in consultation with a medical microbiologist/infectious disease specialist

benzylpenicillin IV 2 million IU 6 times daily for at least 7 days

+

clindamycin IV 600 mg 3 times daily for at least 7 days

Group A streptococcus (toxic strep)

Consider administration of immunoglobulin in consultation with a medical microbiologist/infectious disease specialist

amoxicillin + clavulanic acid IV 1000/200 mg 4 times daily

+

amoxicillin IV 1000 mg 2 times daily

+

amikacin IV 20/20 mg/kg once daily

Type 1 (aerobic and anaerobic mixed flora, streptococci)

≥ 18 years

Contra-indications: Allergy to penicillins*

Дозування Ремарки
cefuroxime IV 1500 mg 3 times daily

+

clindamycin IV 600 mg 3 times daily

+

amikacin IV 20 mg/kg once daily

Unknown pathogen

If NO anaphylactic reaction to penicillins.

Consider administration of immunoglobulin in consultation with a medical microbiologist/infectious disease specialist

cefuroxime IV 1500 mg 3 times daily

+

clindamycin IV 600 mg 3 times daily

Group A streptococcus (toxic strep)

If NO anaphylactic reaction to penicillins.

Consider administration of immunoglobulin in consultation with a medical microbiologist/infectious disease specialist

cefuroxime IV 1500 mg 3 times daily

+

clindamycin IV 600 mg 3 times daily

+

amikacin IV 20 mg/kg once daily

Type 1 (aerobic and anaerobic mixed flora, streptococci)

If NO anaphylactic reaction to penicillins.

Comments

*See protocol Policy for allergy to antibiotics | Radboud UMC

Surgical treatment required