Recommendations
| Дозування | Ремарки | |
|---|---|---|
|
cefazolin IV 2 g single dose
+ metronidazole IV 500 mg single dose |
Small and large bowel surgery, including appendicectomy |
|
|
cefazolin IV 2 g single dose
|
Gastro-duodenal surgery when the lumen is opened |
|
|
cefazolin IV 2 g single dose
|
Open and laparoscopic cholecystectomy: no prophylaxis unless high risk (e.g. age, acute cholecystitis, history of biliary intervention). In that case, cefazolin. |
|
|
Other laparotomies (clean procedures): no prophylaxis |
||
|
piperacillin/tazobactam IV 4.5 g single dose
|
Pancreaticoduodenectomy with stent in situ |
Perioperative antibiotic prophylaxis should be administered within 60 minutes before incision, ideally at the time of induction of anaesthesia.
A single dose of perioperative antibiotic prophylaxis is preferred, but redosing is required for an operative duration of >4 hours (cefazolin) or >2 hours (piperacillin/tazobactam) and for blood loss of >1500 ml.