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Recommendations

≥ 18 years

Indications: if no sepsis

Дозування Ремарки
amoxicillin + clavulanic acid IV 1200 mg 4 times daily for 5 days
≥ 18 years

Indications: In sepsis

Дозування Ремарки
piperacillin/tazobactam IV continuous infusion over 24 hours for 5 days

or

piperacillin/tazobactam IV 4500 mg 4 times daily for 5 days

Dosing for continuous infusion:

First load with 4000/500 mg over 30 minutes, then 16000/2000 mg continuously over 24 hours.

Comments

After recent admission to a hospital or nursing home, or onset > 72 hours after admission, or during antibiotic therapy

Adjust antibiotics according to culture results where possible.

 

Cover Pseudomonas aeruginosa if colonisation/infection within the past year

In case of (suspected) allergy to penicillins and/or cephalosporins:

See protocol: Policy for antibiotic allergy | Radboud UMC

Consult the clinical microbiologist/infectious diseases physician for an alternative regimen.