Recommendations
| Дозування | Ремарки | |
|---|---|---|
|
1st choice
|
flucloxacillin iv 12 g/24 h
+ vancomycin iv |
Loading dose of flucloxacillin: 2 g once, then continuous infusion. For vancomycin dosing see vancomycin | Radboud UMC |
|
2nd choice
|
cefazolin iv 6 g continuous per 24 hours
+ vancomycin iv |
If penicillins are contraindicated* For vancomycin dosing see vancomycin | Radboud UMC (If continuous infusion is not possible, give cefazolin 1 g 6 times daily) |
| Дозування | Ремарки | |
|---|---|---|
|
1st choice
|
piperacillin/tazobactam iv continuous per 24 hours
or piperacillin/tazobactam iv 4000/500 mg 4 times daily |
If continuous infusion: load piperacillin/tazobactam with 4000/500 mg over 30 minutes, then 16000/2000 mg continuous per 24 hours. |
|
2nd choice
|
cefuroxime iv 1500 mg 3 times daily
+ metronidazole oral 500 mg 3 times daily |
If penicillins are contraindicated* |
| Дозування | Ремарки | |
|---|---|---|
|
1st choice
|
piperacillin/tazobactam iv continuous per 24 hours
or piperacillin/tazobactam iv 4500 mg 4 times daily |
If continuous infusion: load piperacillin/tazobactam with 4000/500 mg over 30 minutes, then 16000/2000 mg continuous per 24 hours. |
|
cefuroxime iv 1500 mg 3 times daily
|
If penicillins are contraindicated* |
*See protocol Policy for antibiotic allergy | Radboud UMC
Preferably start antibiotics postoperatively only after cultures have been taken (depending on the clinical situation and diagnostic resources)
Thereafter continue guided by culture results
Follow-up: In consultation with the vascular surgeon and the infectious diseases specialist.