SEP 2.05 Sepsis - suspected central line focus, line sepsis

qSOFA≥2; the central line should be removed.

If qSOFA<2: consult with the microbiologist/infectious diseases physician: in principle antibiotics are not indicated; the central line should be removed.

Loading dose: 1 gram flucloxacillin bolus, followed by continuous infusion

(if continuous infusion is not possible, then flucloxacillin 1 g six times daily)

for eGFR<30 ml/min or haemodialysis/CVVH.

For flucloxacillin dosing, see flucloxacilline | Radboud UMC (antibiotica.app)

For ceftazidime dosing, see ceftazidim | Radboud UMC (antibiotica.app)

qSOFA<2.

For loading and maintenance dosing, see teicoplanine | Radboud UMC (antibiotica.app)

qSOFA≥2. Whether to remove the line should be decided in consultation with the infectious diseases specialist and the primary treating physician.

For loading and maintenance dosing, see teicoplanine | Radboud UMC (antibiotica.app)

In case of:

- proven S. aureus carriage or

- recent S. aureus bacteraemia (within 2 years) or

- exit-site infection (<30 days)

If continuous administration of flucloxacillin: give an initial 1 gram flucloxacillin bolus first.

For eGFR<30 ml/min or haemodialysis/CVVH.

For loading and maintenance dosing, see teicoplanine | Radboud UMC (antibiotica.app)

See ceftazidim | Radboud UMC (antibiotica.app) for dosing.

for eGFR<30 ml/min or haemodialysis/CVVH and in case of:

- proven S. aureus carriage or

- recent S. aureus bacteraemia (within 2 years) or

- exit-site infection (<30 days).

See flucloxacilline | Radboud UMC (antibiotica.app) for dosing.

See cefazoline | Radboud UMC (antibiotica.app)  for dosing.