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Recommendations

≥ 18 years
Dosage Remarks
aciclovir iv 10 mg/kg 3 times daily 10 to 14 days

followed by

valaciclovir po 1000 mg 3 times daily 4 to 6 weeks

With good clinical response an early switch from aciclovir to valaciclovir may be made

≥ 18 years

Indications: In case of progression

Dosage Remarks
aciclovir iv 10 mg/kg 3 times daily

PLUS intravitreal ganciclovir (2 mg/0.1 ml)

OR

PLUS intravitreal foscarnet (2.4 mg/0.1 ml); first choice when aciclovir resistance is suspected

Comments

Secondary prophylaxis may be considered in consultation with a specialist and will partly depend on the immunodeficiency.

The presentation can sometimes be difficult to distinguish from CMV retinitis. If in doubt, start with ganciclovir (see CMV retinitis)