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Recommendations

≥ 18 years
Dosage Remarks
amoxicillin IV 2 g 6 times daily for 6 weeks

+

ceftriaxone IV 2 g twice daily for 6 weeks

+

doxycycline 200 mg once daily for 6 weeks

Native valve

vancomycin IV for 6 weeks

+

ceftriaxone IV 2 g once daily for 6 weeks

+

doxycycline 200 mg once daily for 6 weeks

Prosthetic valve

For vancomycin dosing see vancomycin | Radboud UMC

Comments

Management in consultation with a clinical microbiologist or infectious diseases physician

Consider stopping doxycycline when additional tests for intracellular microorganisms (e.g. Coxiella and Bartonella) are negative.