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Recommendations

≥ 18 years
Dosage Remarks
cefuroxime IV 1500 mg three times daily for 6 weeks

+

metronidazole PO 500 mg three times daily for 2 weeks

+

amikacin IV 20 mg/kg single dose

amikacin is only added in cases of sepsis

If oral intake is possible, metronidazole can also be given orally

Comments

If possible, switch to oral therapy after 2 weeks, depending on the culture; for example clindamycin 600 mg three times daily + ciprofloxacin 500 mg twice daily; total treatment duration 6 weeks.