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Recommendations

≥ 18 years
Dosage Remarks
piperacillin/tazobactam IV continuous over 24 hours

or

piperacillin/tazobactam IV 4000/500 mg 4 times daily

Intra-abdominal focus

Dosing for continuous infusion: first a loading dose of 4000/500 mg over 30 minutes, then 16000/2000 mg continuously per 24 hours.

azithromycin PO 500 mg once daily

Gastroenteritis with fever and/or bloody diarrhoea

Comments

See also ABD 2.1 Bile ducts - cholangitis | Radboud UMC (antibiotica.app)


In case of (suspected) allergy to penicillins and/or cephalosporins:

See Policy for antibiotic allergy | Radboud UMC 

Consult the clinical microbiologist/infectious diseases physician for an alternative regimen.

Other remarks:

Adjust antibiotics where possible based on culture results.

In gastroenteritis without fever or diarrhoea, do not start antibiotics and await microbiological diagnostics.