CAR 2.5 Endocarditis - Cutibacterium (Propionibacterium) spp.

Recommendations

≥ 18 years
	Dosage	Remarks
	benzylpenicillin iv 12 million IU/24 h 6 weeks	Native valve
	benzylpenicillin iv 18 million IU/24 h 6 weeks	Prosthetic valve

≥ 18 years

Indications: Allergy: penicillins contraindicated*
	Dosage	Remarks
	ceftriaxone iv 2 g twice daily 6 weeks	Native valve
	ceftriaxone iv 2 g twice daily 6 weeks	Prosthetic valve

≥ 18 years

Indications: Allergy: cephalosporins contraindicated*
	Dosage	Remarks
	vancomycin iv 6 weeks	Native valve For vancomycin dosing see vancomycin
	vancomycin iv 6 weeks	Prosthetic valve For vancomycin dosing see vancomycin

Rifampicin can be considered in a selected group of patients who are inoperable or who have a paravalvular abscess.