chlamydia (incl. LGV)

Recommendations

≥ 18 years
	Dosage	Remarks
	doxycycline oral 100mg twice daily for 7 days or azithromycin oral 1000mg single dose	SWAB remarks vaginal and/or urethral C. trachomatis infections
	amoxicillin oral 500mg three times daily for 7 days or levofloxacin oral 500mg once daily for 7 days	SWAB remarks vaginal and/or urethral C. trachomatis infections in case of allergy
	doxycycline oral 100mg twice daily for 7 days or azithromycin oral 1000mg single dose	SWAB remarks for rectal infections; doxycycline is first choice
	doxycycline oral 100mg twice daily for 21 days	SWAB remarks rectal LGV infection
	doxycycline oral 100mg twice daily for 7 days or azithromycin oral 1000mg single dose or levofloxacin oral 500mg once daily for 7 days	SWAB remarks chlamydia trachomatis conjunctivitis in adults

≥ 18 years

Indications: current pregnancy
	Dosage	Remarks
	azithromycin oral 1000mg single dose or doxycycline oral 100mg twice daily for 7 days	SWAB remarks 1st trimester
	azithromycin oral 1000mg single dose or amoxicillin oral 500mg three times daily for 7 days	SWAB remarks 2nd and 3rd trimester; azithromycin is first choice

Comments

For the treatment of vaginal and/or urethral Chlamydia infections, doxycycline and azithromycin are equivalent. Depending on the situation, one of the two agents can be chosen in consultation with the patient.

i. Doxycycline is preferred for the treatment of vaginal Chlamydia infections when no rectal test has been taken.
ii. If adherence is in doubt, azithromycin may be considered because of the shorter treatment duration.
iii. If frequent sun exposure during treatment is anticipated, azithromycin may be considered because of phototoxicity.

To prevent ‘ping-pong infections’ current partners should be informed and tested

≥ 18 years

≥ 18 years