Recommendations
| Dosage | Remarks | |
|---|---|---|
|
fluconazole IV loading dose 800 mg, then 400 mg once daily for 6 to 26 weeks
|
SWAB remarks oral if possible; treatment duration depends on clinical course |
|
|
voriconazole IV 6 mg/kg twice daily for 1 day
followed by voriconazole IV 3 mg/kg twice daily |
SWAB remarks for fluconazole resistance guided by susceptibility testing |
|
|
liposomal amphotericin B (Ambisome) IV 3 mg/kg once daily
+ flucytosine IV 25 mg/kg four times daily |
SWAB remarks for fluconazole resistance guided by susceptibility testing |
|
|
amphotericin B lipid complex (Abelcet) IV 5 mg/kg once daily
+ flucytosine IV 25 mg/kg four times daily |
SWAB remarks for fluconazole resistance guided by susceptibility testing |
In endophthalmitis (vitreous invasion), also perform vitrectomy with placement of intravitreal amphotericin B 0.005 mg
Additionally, intravitreal injections on day 0 and day 3: