Hematological malignancies and bone marrow or stem cell transplantation. Indication depends on the local incidence of invasive aspergillosis and the patient population.
In patients with neutropenia after chemotherapy for AML/MDS or HSCT, consider posaconazole: preferably tablets, first day 2 x 300 mg, thereafter 300 mg once daily orally; alternatively suspension 200 mg three times daily orally.
Liver transplantation: In patients at increased risk (end-stage renal failure or haemodialysis, retransplantation, choledochojejunostomy, massive intraoperative blood transfusion, or proven peri-operative colonisation with Candida): fluconazole 400 mg once daily.
Hematological malignancies and bone marrow or stem cell transplantation. Indication depends on the local incidence of invasive aspergillosis and the patient population.
In patients with neutropenia after chemotherapy for AML/MDS or HSCT, consider posaconazole: preferably tablets, first day 2 x 300 mg, thereafter 300 mg once daily orally; alternatively suspension 200 mg three times daily orally.
Liver transplantation: In patients at increased risk (end-stage renal failure or haemodialysis, retransplantation, choledochojejunostomy, massive intraoperative blood transfusion, or proven peri-operative colonisation with Candida): fluconazole 400 mg once daily.
Chronic granulomatous disease (CGD): itraconazole 10 mg/kg/day (max. 200 mg twice daily) orally.
see: Infection protocol - Hematologie-Wijzer