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Recommendations

≥ 18 years

Indications: Oesophageal perforation/head and neck infections

Dosage Remarks
amoxicillin + clavulanic acid IV 1000/100 mg 6 times daily

Community-acquired

piperacillin/tazobactam IV continuous over 24 hours at least 4 weeks

of

piperacillin/tazobactam IV 4500 mg 4 times daily at least 4 weeks

Hospital-acquired

Dosing for continuous infusion:

Piperacillin/tazobactam should first be given as a loading dose of 4000/500 mg over 30 minutes, then 16000/2000 mg continuous over 24 hours.

≥ 18 years

Indications: Postoperative following sternotomy

Dosage Remarks
cefuroxime IV 1500 mg 3 times daily at least 6 weeks

No valve or vascular prosthesis in situ. 

 

cefuroxime IV 1500 mg 3 times daily at least 6 weeks

+

vancomycin IV at least 6 weeks

Valve or vascular prosthesis in situ.

 

 

For vancomycin dosing see vancomycin | Radboud UMC

 

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