Recommendations
| Dosage | Remarks | |
|---|---|---|
|
1st choice
|
flucloxacillin IV 12 g continuous per 24 hours
+ rifampicin oral 450 mg twice daily |
If susceptibility is confirmed Loading dose: 2 g flucloxacillin bolus, then continuous infusion (If continuous infusion is not possible, then flucloxacillin 2 g six times daily) |
|
2nd choice
|
teicoplanin IV
+ rifampicin oral 450 mg twice daily |
For loading and maintenance dosing, see teicoplanin |
| Dosage | Remarks | |
|---|---|---|
|
1st choice
|
clindamycin oral 600 mg three times daily
+ rifampicin oral 450 mg twice daily |
|
|
2nd choice
|
cotrimoxazole (trimethoprim + sulfamethoxazole) oral 960 mg twice daily
+ rifampicin oral 450 mg twice daily |
|
|
3rd choice
|
In case of resistance to clindamycin and cotrimoxazole: consult a microbiologist or infectious disease specialist. |
Add rifampicin only in DAIR or 1-stage exchange. Not in 2-stage exchange or chronic suppressive therapy
Add rifampicin as soon as staphylococci have been identified. If these prove resistant to rifampicin, discontinue rifampicin.
Reduce rifampicin dose to 300 mg twice daily in case of adverse effects